The connections between cancer stem cells (CSCs) and epithelial-mesenchymal transition
(EMT) is critical in cancer initiation, progression, metastasis, and therapy resistance, making …

Doublecortin-like kinase 1 (DCLK1), a protein molecule, has been identified as a tumor stem
cell marker in the cancer cells of gastrointestinal, pancreas, and human colon. DCLK1 …

The transcription factor NANOG regulates self-renewal and pluripotency in embryonic cells,
and its downregulation leads to cell differentiation. Recent studies have linked upregulation …

With the rapid development of cancer treatment, gastrointestinal (GI) cancers are still the
most prevalent malignancies with high morbidity and mortality worldwide. Dysregulation of …

Cartilage lesions are common conditions, affecting elderly and non-athletic populations.
Despite recent advances, cartilage regeneration remains a major challenge today. The …

Esophageal squamous cell carcinoma (ESCC) is a substantial global health burden.
Immune escape mechanisms are important in ESCC progression, enabling cancer cells to …

Gastric cancer is a common tumor of the digestive system, which can occur in any part of the
stomach. Kallikrein 6 (KLK6) is a trypsin‑like serine protease and has been found to be …

Dysfunction of the Hippo pathway is common in esophageal squamous carcinoma (ESCC).
Chaetocin, a small molecular compound isolated from the marine fungus, exhibits potent …

Sex-determining region Y (SRY)-related high mobility group (HMG) box (SOX) proteins are
pivotal transcriptional factors that play essential roles in embryonic development, cell fate …

MicroRNAs (miRNAs) play a vital role in various cell biology processes, including cancer
formation. These small non-coding RNAs could function as diagnostic and prognostic …