Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …

Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates
neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme …

Cholinesterases are important biological targets responsible for regulation of cholinergic
transmission, and their inhibitors are used for the treatment of Alzheimer's disease. To …

Structure-based virtual screening of two libraries containing 567 981 molecules was used to
discover novel, selective BuChE inhibitors, which are potentially superior symptomatic …

Proteins are dynamic entities, and they possess an inherent flexibility that allows them to
function through molecular interactions within the cell, among cells and even between …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

Introduction: Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are
present in the body in large amounts. AChE is an important part of the cholinergic nervous …

Background: Acetylcholinesterase is a serine hydrolase that terminates the action of the
neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Objective: The …

The most successful therapeutic strategy in the treatment of Alzheimer's disease (AD) is
directed toward increasing levels of the neurotransmitter acetylcholine (ACh) by inhibition of …