Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to
address the donor shortage as well as immunologic rejection attributed to cells in …
address the donor shortage as well as immunologic rejection attributed to cells in …
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response
YZ Fu, SY Wang, ZQ Zheng, Y Huang, WW Li… - Cellular & molecular …, 2021 - nature.com
A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious
pathogen that causes high morbidity and substantial mortality. However, the mechanisms by …
pathogen that causes high morbidity and substantial mortality. However, the mechanisms by …
Regulatory networks involving STATs, IRFs, and NFκB in inflammation
E Platanitis, T Decker - Frontiers in immunology, 2018 - frontiersin.org
Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …
tailor these alterations in gene expression to the requirements of the inflammatory process …
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
X Sun, T Liu, J Zhao, H Xia, J Xie, Y Guo… - Nature …, 2020 - nature.com
Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that
underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of …
underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of …
African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity
Y Ran, D Li, MG Xiong, HN Liu, T Feng, ZW Shi… - PLoS …, 2022 - journals.plos.org
ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is
sensed by the innate immune system as well as why it is so virulent remains enigmatic. In …
sensed by the innate immune system as well as why it is so virulent remains enigmatic. In …
MAVS integrates glucose metabolism and RIG-I-like receptor signaling
Q He, Y Huang, L Nie, S Ren, G Xu, F Deng… - Nature …, 2023 - nature.com
MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling in mitochondria,
peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of …
peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of …
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …
Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
The cyclic GMP-AMP synthase (cGAS) is a widely used DNA sensor, which detects cytosolic
DNA species without a preference of self or non-self microbial DNA in interphase to initiate …
DNA species without a preference of self or non-self microbial DNA in interphase to initiate …
Innate immune response to cytoplasmic DNA: mechanisms and diseases
DNA has been known to be a potent immune stimulus for more than half a century. However,
the underlying molecular mechanisms of DNA-triggered immune response have remained …
the underlying molecular mechanisms of DNA-triggered immune response have remained …