Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview
L Huang, C Wu, H Gao, C Xu, M Dai, L Huang, H Hao… - Antibiotics, 2022 - mdpi.com
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …
decreasing the intracellular concentration of drugs. This protective barrier consists of a …
Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer
Highlights•Phages drive horizontal gene transfer between prokaryotes.•Lysogenic
conversion provides novel adaptive traits, at the cost of eventual lysis.•Prophages account …
conversion provides novel adaptive traits, at the cost of eventual lysis.•Prophages account …
Phages rarely encode antibiotic resistance genes: a cautionary tale for virome analyses
Antibiotic resistance genes (ARGs) are pervasive in gut microbiota, but it remains unclear
how often ARGs are transferred, particularly to pathogens. Traditionally, ARG spread is …
how often ARGs are transferred, particularly to pathogens. Traditionally, ARG spread is …
The diverse impacts of phage morons on bacterial fitness and virulence
VL Taylor, AD Fitzpatrick, Z Islam, KL Maxwell - Advances in virus research, 2019 - Elsevier
The viruses that infect bacteria, known as phages, are the most abundant biological entity on
earth. They play critical roles in controlling bacterial populations through phage-mediated …
earth. They play critical roles in controlling bacterial populations through phage-mediated …
The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs
S Chetri - Frontiers in Microbiology, 2023 - frontiersin.org
Efflux pumps function as an advanced defense system against antimicrobials by reducing
the concentration of drugs inside the bacteria and extruding the substances outside. Various …
the concentration of drugs inside the bacteria and extruding the substances outside. Various …
Bacteriophage interactions with marine pathogenic vibrios: implications for phage therapy
A global distribution in marine, brackish, and freshwater ecosystems, in combination with
high abundances and biomass, make vibrios key players in aquatic environments, as well …
high abundances and biomass, make vibrios key players in aquatic environments, as well …
Graded decisions in the human brain
Decision-makers objectively commit to a definitive choice, yet at the subjective level, human
decisions appear to be associated with a degree of uncertainty. Whether decisions are …
decisions appear to be associated with a degree of uncertainty. Whether decisions are …
[HTML][HTML] Global genomic epidemiology of Streptococcus pyogenes
Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide
causing a range of clinical manifestations in humans. Colonizing a range of ecological …
causing a range of clinical manifestations in humans. Colonizing a range of ecological …
Type M resistance to macrolides is due to a two-gene efflux transport system of the ATP-binding cassette (ABC) superfamily
F Iannelli, F Santoro, M Santagati… - Frontiers in …, 2018 - frontiersin.org
The mef (A) gene was originally identified as the resistance determinant responsible for type
M resistance to macrolides, a phenotype frequently found in clinical isolates of …
M resistance to macrolides, a phenotype frequently found in clinical isolates of …
Global diversity and distribution of prophages are lineage-specific within the Ralstonia solanacearum species complex
STE Greenrod, M Stoycheva, J Elphinstone, VP Friman - BMC genomics, 2022 - Springer
Background Ralstonia solanacearum species complex (RSSC) strains are destructive plant
pathogenic bacteria and the causative agents of bacterial wilt disease, infecting over 200 …
pathogenic bacteria and the causative agents of bacterial wilt disease, infecting over 200 …