Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …

Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …

Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD
therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence …

Human genetic studies have recently suggested that the postsynaptic activity-regulated
cytoskeleton-associated protein (Arc) complex is a convergence signal for several genes …

Astrocytes display diverse morphologies in different regions of the central nervous system.
Whether astrocyte diversity is attributable to developmental processes and bears functional …

The Arc gene is robustly transcribed in specific neural ensembles in response to experience-
driven activity. Upon induction, Arc mRNA is transported to dendrites, where it can be rapidly …

Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and
exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent …

ADHD, schizophrenia and bipolar disorder are psychiatric diseases with a strong genetic
component which share dopaminergic alterations. Dopamine transporter (DAT) genetics …

Background Kynurenine 3-monooxygenase converts kynurenine to 3-hydroxykynurenine,
and its inhibition shunts the kynurenine pathway—which is implicated as dysfunctional in …