Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

[HTML][HTML] Engineering Nicotiana benthamiana as a platform for natural product biosynthesis

D Golubova, C Tansley, H Su, NJ Patron - Current Opinion in Plant Biology, 2024 - Elsevier
Nicotiana benthamiana is a model plant, widely used for research. The susceptibility of
young plants to Agrobacterium tumefaciens has been utilised for transient gene expression …

Enhanced precision and efficiency in metabolic regulation: compartmentalized metabolic engineering

R Wang, Y Su, W Yang, H Zhang, J Wang… - Bioresource Technology, 2024 - Elsevier
Metabolic engineering has witnessed remarkable advancements, enabling successful large-
scale, cost-effective and efficient production of numerous compounds. However, the …

Squalene lipotoxicity in a lipid droplet‐less yeast mutant is linked to plasma membrane dysfunction

Z Csáky, M Garaiová, M Kodedová, M Valachovič… - Yeast, 2020 - Wiley Online Library
Squalene is a naturally occurring triterpene with wide industrial applications. Due to limited
natural resources, production of this valuable lipid in yeast is of high commercial relevance …

Engineered poplar for bioproduction of the triterpene squalene

JD Bibik, A Sahu, B Kim, F Unda… - Plant Biotechnology …, 2024 - Wiley Online Library
Building sustainable platforms to produce biofuels and specialty chemicals has become an
increasingly important strategy to supplement and replace fossil fuels and petrochemical …

Plant-derived strategies to fight against severe acute respiratory syndrome coronavirus 2

W Li, T Ding, H Chang, Y Peng, J Li, X Liang… - European Journal of …, 2024 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused an
unprecedented crisis, which has been exacerbated because specific drugs and treatments …

Biosynthesis of bridged tricyclic sesquiterpenes in Inula lineariifolia

Y Wu, X Chen, F Hao, Y Liu, W Luo, Y Zhu… - The Plant …, 2024 - Wiley Online Library
Presilphiperfolane‐type sesquiterpenes represent a unique group of atypical
sesquiterpenoids characterized by their distinctive tricyclic structure. They have significant …

[HTML][HTML] The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production

Y Li, Y Zhang, X He, Z Guo, N Yang, G Bai, J Zhao… - Metabolites, 2024 - mdpi.com
Mitochondrial metabolism plays a pivotal role in regulating the synthesis of secondary
metabolites, which are crucial for the survival and adaptation of organisms. These …

Engineering Terpene Production Pathways in Methylobacterium extorquens AM1

A Hurt, JD Bibik, NC Martinez-Gomez, B Hamberger - Microorganisms, 2024 - mdpi.com
Terpenes are diverse specialized metabolites naturally found within plants and have
important roles in inter-species communication, adaptation and interaction with the …

Proteins in Synthetic Biology with Agricultural and Environmental Applications

MM Mann, TN Vigil, SM Felton, WE Fahy, MA Kinkeade… - SynBio, 2022 - mdpi.com
Synthetic biology tools have become increasingly prevalent as we look to nature for
biological approaches to complex problems. With an ever-growing global population, issues …