The primate malaria parasites Plasmodium malariae, Plasmodium brasilianum and Plasmodium ovale spp.: genomic insights into distribution, dispersal and host …

HP Fuehrer, S Campino, CJ Sutherland - Malaria journal, 2022 - Springer
During the twentieth century, there was an explosion in understanding of the malaria
parasites infecting humans and wild primates. This was built on three main data sources …

Selecting analytical biomarkers for diagnostic applications: a first principles approach

SA Byrnes, BH Weigl - Expert Review of Molecular Diagnostics, 2018 - Taylor & Francis
Introduction: Biomarkers are objective indications of a medical state that can be measured
accurately and reproducibly. Traditional biomarkers enable diagnosis of disease through …

The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

HC Slater, A Ross, I Felger, NE Hofmann… - Nature …, 2019 - nature.com
Malaria infections occurring below the limit of detection of standard diagnostics are common
in all endemic settings. However, key questions remain surrounding their contribution to …

[HTML][HTML] Performance of a high-sensitivity rapid diagnostic test for Plasmodium falciparum malaria in asymptomatic individuals from Uganda and Myanmar and naive …

S Das, IK Jang, B Barney, R Peck, JC Rek… - The American journal …, 2017 - ncbi.nlm.nih.gov
Sensitive field-deployable diagnostic tests can assist malaria programs in achieving
elimination. The performance of a new Alere™ Malaria Ag Pf Ultra Sensitive rapid diagnostic …

Pfhrp2-Deleted Plasmodium falciparum Parasites in the Democratic Republic of the Congo: A National Cross-sectional Survey

JB Parr, R Verity, SM Doctor, M Janko… - The Journal of …, 2017 - academic.oup.com
Abstract Background. Rapid diagnostic tests (RDTs) account for more than two-thirds of
malaria diagnoses in Africa. Deletions of the Plasmodium falciparum hrp2 (pfhrp2) gene …

Plasmodium falciparum parasite prevalence in East Africa: Updating data for malaria stratification

VA Alegana, PM Macharia, S Muchiri… - PLOS global public …, 2021 - journals.plos.org
The High Burden High Impact (HBHI) strategy for malaria encourages countries to use
multiple sources of available data to define the sub-national vulnerabilities to malaria risk …

Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa

OJ Watson, HC Slater, R Verity, JB Parr… - Elife, 2017 - elifesciences.org
Rapid diagnostic tests (RDTs) have transformed malaria diagnosis. The most prevalent P.
falciparum RDTs detect histidine-rich protein 2 (PfHRP2). However, pfhrp2 gene deletions …

Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood …

S Das, RB Peck, R Barney, IK Jang, M Kahn, M Zhu… - Malaria journal, 2018 - Springer
Background As malaria endemic countries shift from control to elimination, the proportion of
low density Plasmodium falciparum infections increases. Current field diagnostic tools, such …

Field evaluation of diagnostic performance of malaria rapid diagnostic tests in western Kenya

EW Wanja, N Kuya, C Moranga, M Hickman… - Malaria journal, 2016 - Springer
Background Malaria continues to be a major burden in the endemic regions of Kenya.
Health outcomes associated with case management are dependent on the use of …

Impact of Plasmodium falciparum gene deletions on malaria rapid diagnostic test performance

ML Gatton, A Chaudhry, J Glenn, S Wilson, Y Ah… - Malaria Journal, 2020 - Springer
Background Malaria rapid diagnostic tests (RDTs) have greatly improved access to
diagnosis in endemic countries. Most RDTs detect Plasmodium falciparum histidine-rich …