Glaucoma can be inherited as a mendelian autosomal-dominant or autosomal-recessive
trait, or as a complex multifactorial trait. Genetic approaches have helped define the …

Glaucoma a debilitating disease, is globally the second most common kind of permanent
blindness. Primary open-angle glaucoma (POAG) is its most prevalent form and is often …

Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role
in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction …

A family of olfactomedin domain-containing proteins consists of at least 13 members in
mammals. Although the first protein belonging to this family, olfactomedin, was isolated and …

Over a decade has passed since myocilin was identified as the first gene linked to early and
late-onset primary open-angle glaucoma. During this time, considerable effort has been put …

The discovery in the human ocular ciliary body of glaucoma-associated genes (ie, MYOC,
CYP1B1), neuroendocrine processing enzymes, neuroendocrine peptides, steroid …

Olfactomedin proteins are characterized by a conserved domain of\texorpdfstring~\
textasciitilde250 amino acids corresponding to the olfactomedin archetype first discovered in …

These findings represent advances in understanding physiological and pathogenic
mechanisms within the trabecular meshwork that are relevant to intraocular pressure …

Primary open angle glaucoma (POAG) is a common late-onset neurodegenerative disease.
Ocular hypertension represents a major risk factor, but POAG etiology remains poorly …

Glaucoma is a group of heterogeneous optic neuropathies with complex genetic basis.
Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) …