Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

The microtubule-associated protein tau is involved in a number of neurodegenerative
disorders, including Alzheimer's disease. Previous studies have linked oxidative stress and …

There are currently no disease-modifying therapies for the treatment of tauopathies, a group
of progressive neurodegenerative disorders that are pathologically defined by the presence …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

A given cell makes exchanges with its neighbors through a variety of means ranging from
diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin …