Advances and challenges in malaria vaccine development

PD Crompton, SK Pierce… - The Journal of clinical …, 2010 - Am Soc Clin Investig
Malaria caused by Plasmodium falciparum remains a major public health threat, especially
among children and pregnant women in Africa. An effective malaria vaccine would be a …

A review of malaria vaccine clinical projects based on the WHO rainbow table

L Schwartz, GV Brown, B Genton, VS Moorthy - Malaria journal, 2012 - Springer
Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS,
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

MML Poon, K Rybkina, Y Kato, M Kubota… - Science …, 2021 - science.org
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized
in blood; however, most functions of protective immunity must be accomplished in tissues …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

[HTML][HTML] Recent advances in recombinant protein-based malaria vaccines

SJ Draper, E Angov, T Horii, LH Miller, P Srinivasan… - Vaccine, 2015 - Elsevier
Plasmodium parasites are the causative agent of human malaria, and the development of a
highly effective vaccine against infection, disease and transmission remains a key priority. It …

Toward the development of effective transmission-blocking vaccines for malaria

D Nikolaeva, SJ Draper, S Biswas - Expert review of vaccines, 2015 - Taylor & Francis
The continued global burden of malaria can in part be attributed to a complex lifecycle, with
both human hosts and mosquito vectors serving as transmission reservoirs. In preclinical …

Development of malaria transmission-blocking vaccines: from concept to product

Y Wu, RE Sinden, TS Churcher, T Tsuboi… - Advances in …, 2015 - Elsevier
Despite decades of effort battling against malaria, the disease is still a major cause of
morbidity and mortality. Transmission-blocking vaccines (TBVs) that target sexual stage …

Vaccination with sporozoites: models and correlates of protection

YS Goh, D McGuire, L Rénia - Frontiers in immunology, 2019 - frontiersin.org
Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple
control interventions need to be in place simultaneously to achieve this goal. In addition to …

Transmission-blocking strategies: the roadmap from laboratory bench to the community

D Gonçalves, P Hunziker - Malaria Journal, 2016 - Springer
Malaria remains one of the most prevalent tropical and infectious diseases in the world, with
an estimated more than 200 million clinical cases every year. In recent years, the mosquito …

New dimensions in the field of antimalarial research against malaria resurgence

AK Narula, CS Azad, LM Nainwal - European Journal of Medicinal …, 2019 - Elsevier
Malaria is a life threatening disease caused by microscopic parasites called Plasmodium
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …