Genetics of coronary artery disease: discovery, biology and clinical translation

AV Khera, S Kathiresan - Nature Reviews Genetics, 2017 - nature.com
Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

Common risk factors for heart failure and cancer

WC Meijers, RA de Boer - Cardiovascular research, 2019 - academic.oup.com
Cardiovascular (CV) disease and cancer are the leading causes of death., Over the last
decades, it has been appreciated that both CV disease and cancer are more common in …

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

S Maschalidi, P Mehrotra, BN Keçeli, HKL De Cleene… - Nature, 2022 - nature.com
Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10
people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to …

Prospective epidemiological research studies in Iran (the PERSIAN Cohort Study): rationale, objectives, and design

H Poustchi, S Eghtesad, F Kamangar… - American journal of …, 2018 - academic.oup.com
Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is
on the rise, in parallel with global rates. Many risk factors associated with NCDs are …

DYRK1B-STAT3 drives cardiac hypertrophy and heart failure by impairing mitochondrial bioenergetics

L Zhuang, K Jia, C Chen, Z Li, J Zhao, J Hu, H Zhang… - Circulation, 2022 - Am Heart Assoc
Background: Heart failure is a global public health issue that is associated with increasing
morbidity and mortality. Previous studies have suggested that mitochondrial dysfunction …

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature review

AD Frankenberg, AF Reis, F Gerchman - Archives of endocrinology …, 2017 - SciELO Brasil
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance-
abnormalities of glucose metabolism typically found in subjects with obesity-are major …

Nonalcoholic steatohepatitis

A Suzuki, AM Diehl - Annual review of medicine, 2017 - annualreviews.org
Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-
related deaths worldwide. NASH is strongly associated with obesity and the metabolic …

Cardiovascular disease and cancer: evidence for shared disease pathways and pharmacologic prevention

F Masoudkabir, N Sarrafzadegan, C Gotay… - Atherosclerosis, 2017 - Elsevier
Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity
worldwide. Strategies to improve their treatment and prevention are global priorities and …

[HTML][HTML] Reverse cardio-oncology: Exploring the effects of cardiovascular disease on cancer pathogenesis

GJ Koelwyn, JP Aboumsallem, KJ Moore… - Journal of molecular and …, 2022 - Elsevier
The field of cardio-oncology has emerged in response to the increased risk of
cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a …