Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Our work has shown that certain ruthenium (II) arene complexes exhibit promising
anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

This paper is aimed at introducing the organometallic chemist to the fascinating area of
organometallic pharmaceuticals. It commences by identifying the properties of …

Late-stage modification of drug molecules is a fast method to introduce diversity into the
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …

Resistance to chemotherapy is a current clinical problem, especially in the treatment of
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …

The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Recent clinical reports have highlighted the increasing occurrence of drug resistance of
known therapeutics. Particularly, antibiotic resistant microorganisms and multidrug …

Although most antibiotics do not need metal ions for their biological activities, there are a
number of antibiotics that require metal ions to function properly, such as bleomycin (BLM) …

The medical uses of gold have a long history; rheumatoid arthritis is currently treated with
gold-based drugs and there is increasing interest in the application of gold complexes as …