Epstein–Barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent
infections that result in a variety of human diseases, including lymphoproliferative disorders …

Acute lymphoblastic leukemia (ALL) is a malignant clonal expansion of lymphoid
hematopoietic precursors that exhibit developmental arrest at varying stages of …

In this study we examine the mechanisms of dynamic DNA methylation of the p15 ink4b
tumor suppressor gene. Using conventional ChIP and ChiPseq, we identify the p15 ink4b …

Background: Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) genes are frequently
altered in acute lymphoblastic leukaemia (ALL) patients. The aim of this meta-analysis was …

The inactivation of tumor suppressor genes located within 9p21 locus (CDKN2A, CDKN2B)
occurs in up to 30% of children with B-cell precursor acute lymphoblastic leukemia (BCP …

DNA methylation is a dynamic process influencing gene expression by altering either coding
or non-coding loci. Despite advances in treatment of Acute Lymphoblastic Leukemia (ALL); …

Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic
leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age …

One of the most frequent genes affected in pediatric ALL is the CDKN2A/2B gene, acting as
a secondary cooperating event and playing an important role in cell-cycle regulation and …

The p15Ink4b gene is frequently hypermethylated in myeloid neoplasia and has been
demonstrated to be a tumor suppressor. Since it is a member of the INK4b family of cyclin …

Background The biology of acute myeloid leukemia (AML) is complex and includes both
genetic and epigenetic aberrations. We addressed the combined consequences of promoter …