Developing benzylisoquinoline alkaloid-enriched opium poppy via CRISPR-directed genome editing: A review

Z Aghaali, MR Naghavi - BMC Plant Biology, 2024 - Springer
Among plant-derived secondary metabolites are benzylisoquinoline alkaloids (BIAs) that
play a vital role in medicine. The most conspicuous BIAs frequently found in opium poppy …

Identifying and treating codeine dependence: a systematic review

S Nielsen, T MacDonald… - Medical Journal of …, 2018 - Wiley Online Library
Objectives: Codeine dependence is a significant public health problem, motivating the
recent rescheduling of codeine in Australia (1 February 2018). To provide information for …

The extent and correlates of community‐based pharmaceutical opioid utilisation in Australia

L Degenhardt, N Gisev, E Cama… - … and Drug Safety, 2016 - Wiley Online Library
Purpose There has been concern regarding the increasing use of opioids and related harm.
We present data on opioid utilisation across Australia and consider sociodemographic …

Deaths from opioid overdosing: implications of coroners' inquest reports 2008–2012 and annual rise in opioid prescription rates: a population-based cohort study

EE Shipton, AJ Shipton, JA Williman, EA Shipton - Pain and Therapy, 2017 - Springer
Introduction In the late 1990s multiple physicians and advocacy organizations promoted
increased use of opioids for the treatment of acute, chronic and cancer pain. There has been …

'Codeine is my companion': misuse and dependence on codeine containing medicines in Ireland

MC Van Hout, A Horan, K Santlal, E Rich… - Irish Journal of …, 2018 - cambridge.org
ObjectivesGlobal concern around over the counter availability of codeine containing
products and risk of misuse, dependence and related harms are evident. A …

Over-the-counter codeine—from therapeutic use to dependence, and the grey areas in between

S Nielsen, MC Van Hout - Non-medical and illicit use of psychoactive …, 2017 - Springer
Codeine is a widely used analgesic, that is available for sale in pharmacies over the counter
(OTC) in a number of countries including the UK, South Africa, Ireland, France and Australia …

An ecological study of the extent and factors associated with the use of prescription and over-the-counter codeine in Australia

N Gisev, S Nielsen, E Cama, B Larance… - European journal of …, 2016 - Springer
Purpose The extent and factors associated with codeine use in the community remain poorly
understood despite the widespread global use of codeine. The aim of this study was to …

Changes in non-opioid substitution treatment episodes for pharmaceutical opioids and heroin from 2002 to 2011

S Nielsen, A Roxburgh, R Bruno, N Lintzeris… - Drug and Alcohol …, 2015 - Elsevier
Background There has been a well-documented increase in the non-medical use of
pharmaceutical opioids (PO) worldwide. However, there has been little detailed examination …

Current opioid access, use, and problems in Australasian jurisdictions

N Gisev, G Campbell, S Lalic, S Larney… - Current Addiction …, 2018 - Springer
Abstract Purpose of Review To summarize current patterns of pharmaceutical opioid use,
extra-medical use, and harms across Australasia, with a focus on Australia and New …

Codeine misuse and dependence in South Africa: Perspectives of addiction treatment providers

CDH Parry, E Rich, MC Van Hout, P Deluca - South African medical journal, 2017 - ajol.info
Background. General practitioners are referring patients with codeine-related problems to
specialist treatment facilities, but little is known about the addiction treatment providers, the …