Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …

Parkinson's disease (PD) is the second most common neurodegenerative disease, the main
pathological hallmark of which is the accumulation of α-synuclein (α-syn) and the formation …

Amyloid β-peptide (Aβ), the pathogenic agent of Alzheimer disease, is a physiological
metabolite whose levels are constantly controlled in normal brain. Recent studies have …

Alzheimer's disease (AD) is characterized by β-amyloid plaques and intraneuronal τ
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …

Although the exact etiology of Alzheimer's disease (AD) is a topic of debate, the consensus
is that the accumulation of β-amyloid (Aβ) peptides in the senile plaques is one of the …

Recent evidence implicates exosomes in the aggregation of Aβ and spreading of tau in
Alzheimer9s disease. In neural cells, exosome formation can be blocked by inhibition or …

GM1 ganglioside occurs widely in vertebrate tissues, where it exhibits many essential
functions, both in the plasma membrane and intracellular loci. Its essentiality is revealed in …

Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated,
acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or …

Elevated levels of amyloid-β peptide (Aβ) in the human brain are linked to the pathogenesis
of Alzheimer disease. Recent in vitro studies have demonstrated that extracellular Aβ can …

High fat diets and sedentary lifestyles are becoming major concerns for Western countries.
They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a …