Bioreactor technologies for enhanced organoid culture
An organoid is a 3D organization of cells that can recapitulate some of the structure and
function of native tissue. Recent work has seen organoids gain prominence as a valuable …
function of native tissue. Recent work has seen organoids gain prominence as a valuable …
[HTML][HTML] Complete human day 14 post-implantation embryo models from naive ES cells
The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …
and technical challenges associated with intrauterine development after implantation …
Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids
In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
[HTML][HTML] Human embryo models: the importance of national policy and governance review
Highlights●Transparent, enforceable regulations are beneficial to scientists and the
public.●Regulations must be nationally specific and should reflect an overlapping …
public.●Regulations must be nationally specific and should reflect an overlapping …
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies
A Blasimme, J Sugarman - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cells can be used to derive in vitro models recapitulating post-
implantation human embryos. While useful for research purposes, such integrated embryo …
implantation human embryos. While useful for research purposes, such integrated embryo …
An update on human pre-and peri-implantation development: a blueprint for blastoids
Despite over 40 years following the first birth from medically assisted reproduction (MAR)
technologies, mechanisms underlying the key developmental events during the first 7 days …
technologies, mechanisms underlying the key developmental events during the first 7 days …
In preprints: opportunities to unravel the earliest stages of human development using stem cell-based embryo models
Several exciting advances have enabled the derivation of stem cell-based embryo-like
models (SCBEMs). Such models allow us to interrogate previously intractable questions in …
models (SCBEMs). Such models allow us to interrogate previously intractable questions in …
Dawn of development: exploring early human embryogenesis using stem cells
TTKK Tam, S Xu, P Liu, A De Los Angeles - Cell Stem Cell, 2023 - cell.com
Exploring the early stages of human embryonic development poses significant difficulties
owing to ethical and technical limitations. Two recent studies in Nature report the self …
owing to ethical and technical limitations. Two recent studies in Nature report the self …
Modeling specific aneuploidies: from karyotype manipulations to biological insights
MA Truong, P Cané-Gasull, SMA Lens - Chromosome Research, 2023 - Springer
An abnormal chromosome number, or aneuploidy, underlies developmental disorders and
is a common feature of cancer, with different cancer types exhibiting distinct patterns of …
is a common feature of cancer, with different cancer types exhibiting distinct patterns of …
Interspecies control of development during mammalian gastrulation
L Simpson, R Alberio - Emerging Topics in Life Sciences, 2023 - portlandpress.com
Gastrulation represents a pivotal phase of development and aberrations during this period
can have major consequences, from minor anatomical deviations to severe congenital …
can have major consequences, from minor anatomical deviations to severe congenital …