Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Immune cell trafficking is a complex and tightly regulated process that is indispensable for
the body's fight against pathogens. However, it is also increasingly acknowledged that …

Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

This is the second European Crohn's and Colitis Organisation [ECCO] evidence-based
consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and …

Comorbid primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD)
represent a unique disease phenotype with a different risk profile than PSC or IBD alone …

Primary sclerosing cholangitis (PSC) is a progressive liver disease, histologically
characterized by inflammation and fibrosis of the bile ducts, and clinically leading to multi …

Background & Aims Gut-homing lymphocytes that express the integrin α4β7 and CCR9
might contribute to development of primary sclerosing cholangitis (PSC). Vedolizumab …

Abstract Background and Aims The “gut homing” hypothesis suggests the pathogenesis of
primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut …

While bile acids are important for both digestion and signalling, hydrophobic bile acids can
be harmful, especially when in high concentrations. Mechanisms for the protection of …