Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

MacroH2A has established tumour suppressive functions in melanoma and other cancers,
but an unappreciated role in the tumour microenvironment. Using an autochthonous …

Senescence and epigenetic alterations stand out as two well-characterized hallmarks of
aging. When cells become senescent, they cease proliferation and release inflammatory …

Incomplete understanding of metastatic disease mechanisms continues to hinder effective
treatment of cancer. Despite remarkable advancements toward the identification of …

Purpose: The integrated stress response (ISR) kinase PERK serves as a survival factor for
both proliferative and dormant cancer cells. We aim to validate PERK inhibition as a new …

Disseminated cancer cells (DCCs) in secondary organs can remain dormant for years to
decades before reactivating into overt metastasis. Microenvironmental signals leading to …

The last few years have seen an increasing number of discoveries which collectively
demonstrate that histone and DNA modifying enzyme modulate different stages of …

Epigenetic regulation, which is characterized by reversible and heritable genetic alterations
without changing DNA sequences, has recently been increasingly studied in diseases …

Cancer cell dormancy is a critical phase in cancer development, wherein cancer cells exist
in a latent state marked by temporary but reversible growth arrest. This dormancy phase …