Reconstitution of membrane proteins in phospholipid bilayer nanodiscs
TK Ritchie, YV Grinkova, TH Bayburt, IG Denisov… - Methods in …, 2009 - Elsevier
Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile
tool among model membrane systems to functionally reconstitute membrane proteins …
tool among model membrane systems to functionally reconstitute membrane proteins …
ABC efflux pump-based resistance to chemotherapy drugs
PDW Eckford, FJ Sharom - Chemical reviews, 2009 - ACS Publications
Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Y Kim, J Chen - Science, 2018 - science.org
The multidrug transporter permeability (P)–glycoprotein is an adenosine triphosphate (ATP)–
binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein …
binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein …
Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans
Abstract P-glycoprotein (P-gp) is an ATP-binding cassette transporter that confers multidrug
resistance in cancer cells,. It also affects the absorption, distribution and clearance of cancer …
resistance in cancer cells,. It also affects the absorption, distribution and clearance of cancer …
Refined structures of mouse P‐glycoprotein
J Li, KF Jaimes, SG Aller - Protein Science, 2014 - Wiley Online Library
The recently determined C. elegans P‐glycoprotein (Pgp) structure revealed significant
deviations compared to the original mouse Pgp structure, which suggested possible …
deviations compared to the original mouse Pgp structure, which suggested possible …
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)
ATP binding cassette (ABC) drug transporters play an important role in cancer drug
resistance, protection against xenobiotics, and in general in the passage of drugs through …
resistance, protection against xenobiotics, and in general in the passage of drugs through …
Structure and mechanism of ATP-binding cassette transporters
KP Locher - … Transactions of the Royal Society B …, 2009 - royalsocietypublishing.org
ATP-binding cassette (ABC) transporters constitute a large superfamily of integral
membrane proteins that includes both importers and exporters. In recent years, several …
membrane proteins that includes both importers and exporters. In recent years, several …
Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
AWR Serohijos, T Hegedűs… - Proceedings of the …, 2008 - National Acad Sciences
Deletion of phenylalanine-508 (Phe-508) from the N-terminal nucleotide-binding domain
(NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the …
(NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the …
Functional expression and characterization of Arabidopsis ABCB, AUX 1 and PIN auxin transporters in Schizosaccharomyces pombe
Heterologous expression systems based on tobacco BY‐2 cells, Arabidopsis cell cultures,
Xenopus oocytes, Saccharomyces cerevisiae, and human HeLa cells have been used to …
Xenopus oocytes, Saccharomyces cerevisiae, and human HeLa cells have been used to …
[HTML][HTML] Comparison of mechanistic transport cycle models of ABC exporters
D Szöllősi, D Rose-Sperling, UA Hellmich… - Biochimica et Biophysica …, 2018 - Elsevier
ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out
essential substrate transport reactions across cell membranes. Their transmembrane …
essential substrate transport reactions across cell membranes. Their transmembrane …