Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss. We
investigated the role of Wnt signaling in maintaining the BRB by limiting transcytosis. Mice …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Osteoporosis is a systemic bone disease characterized by low bone mass,
microarchitectural deterioration, increased bone fragility, and fracture susceptibility. It …

Retinal neovascularization is typically accompanied by hypoxia-induced oxidative injury in
the vascular system. This study developed an ultrasmall (6–8 nm) platinum (Pt) nanozyme …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

During development, the central nervous system (CNS) vasculature grows to precisely meet
the metabolic demands of neurons and glia. In addition, the vast majority of the CNS …

As a common ocular complication and microangiopathy of type 2 diabetic mellitus, diabetic
retinopathy (DR) can lead to vision loss or even blindness in diabetic patients. At present …