Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation

F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …

Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus

A Horn, WJ Neumann, K Degen… - Human brain …, 2017 - Wiley Online Library
Enhanced beta‐band activity recorded in patients suffering from Parkinson's Disease (PD)
has been described as a potential physiomarker for disease severity. Beta power is …

[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review

Z Yin, G Zhu, B Zhao, Y Bai, Y Jiang… - Neurobiology of …, 2021 - Elsevier
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …

[HTML][HTML] The pathophysiology of Parkinson's disease tremor

MF Dirkx, M Bologna - Journal of the Neurological Sciences, 2022 - Elsevier
Tremor is one of the primary motor symptoms of Parkinson's disease (PD), and it is
characterized by a highly phenomenological heterogeneity. Clinical and experimental …

Complexity analysis of EEG, MEG, and fMRI in mild cognitive impairment and Alzheimer's disease: a review

J Sun, B Wang, Y Niu, Y Tan, C Fan, N Zhang, J Xue… - Entropy, 2020 - mdpi.com
Alzheimer's disease (AD) is a degenerative brain disease with a high and irreversible
incidence. In recent years, because brain signals have complex nonlinear dynamics, there …

[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders

WJ Neumann, RS Turner, B Blankertz, T Mitchell… - …, 2019 - Elsevier
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

[HTML][HTML] IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG)

R Hari, S Baillet, G Barnes, R Burgess, N Forss… - Clinical …, 2018 - Elsevier
Magnetoencephalography (MEG) records weak magnetic fields outside the human head
and thereby provides millisecond-accurate information about neuronal currents supporting …

Closed‐loop deep brain stimulation for essential tremor based on thalamic local field potentials

S He, F Baig, A Mostofi, A Pogosyan… - Movement …, 2021 - Wiley Online Library
Background High‐frequency thalamic stimulation is an effective therapy for essential tremor,
which mainly affects voluntary movements and/or sustained postures. However, continuous …

Changing views of the pathophysiology of Parkinsonism

T Wichmann - Movement Disorders, 2019 - Wiley Online Library
Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia)
have a long history and primarily model the consequences of dopamine loss in the basal …