Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue
disorder with variable clinical presentations, that affects both adults and children. It is …

Morphea is a rare autoimmune condition causing inflammation and sclerosis of the skin and
underlying soft tissue. It is characterized by periods of activity (inflammation admixed with …

The term 'sclerosing diseases of the skin'comprises specific dermatological entities, which
have fibrotic changes of the skin in common. These diseases mostly manifest in different …

Methotrexate treatment has greatly improved outcome for most jLS patients but a substantial
portion have refractory cutaneous and/or extracutaneous disease. Treatment response …

Objective To evaluate the safety and efficacy of abatacept treatment for refractory juvenile
localized scleroderma (jLS) in a retrospective study. Methods A multicentre cohort study was …

Localized scleroderma (LS), also known as morphea, is an idiopathic inflammatory and
sclerosing disorder affecting the skin and subcutaneous structures. 1, 2 Although skin …

Systemic sclerosis (SSc) and morphea are autoimmune sclerosing diseases that cause
significant morbidity, and in the case of SSc, mortality. The pathogenesis of both SSc and …

Introduction Morphea is a chronic autoimmune fibrosing condition of the skin and underlying
tissue with the potential for significant disease-associated morbidity. While the exact etiology …

Abstract Parry Romberg Syndrome (PRS) and en coup de sabre (ECDS) are head variants
of linear morphea with functional and structural implications. This study describes the clinical …

Die vorliegende aktualisierte S2k‐Leitlinie befasst sich mit der Diagnostik und der Therapie
der zirkumskripten Sklerodermie (ZS). Diese umfasst ein Spektrum sklerotischer …