Computational models for clinical applications in personalized medicine—guidelines and recommendations for data integration and model validation
CB Collin, T Gebhardt, M Golebiewski… - Journal of personalized …, 2022 - mdpi.com
The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …
different sources, as well as harmonized integrative analysis of large-scale clinical health …
Synthetic gene circuits for the detection, elimination and prevention of disease
F Sedlmayer, D Aubel, M Fussenegger - Nature biomedical engineering, 2018 - nature.com
In living organisms, naturally evolved sensors that constantly monitor and process
environmental cues trigger corrective actions that enable the organisms to cope with …
environmental cues trigger corrective actions that enable the organisms to cope with …
Gateways to the FANTOM5 promoter level mammalian expression atlas
M Lizio, J Harshbarger, H Shimoji, J Severin… - Genome biology, 2015 - Springer
The FANTOM5 project investigates transcription initiation activities in more than 1,000
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …
systemsDock: a web server for network pharmacology-based prediction and analysis
We present systemsDock, a web server for network pharmacology-based prediction and
analysis, which permits docking simulation and molecular pathway map for comprehensive …
analysis, which permits docking simulation and molecular pathway map for comprehensive …
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …
Systems approaches to investigate the role of NF-κB signaling in aging
M Haga, M Okada - Biochemical Journal, 2022 - portlandpress.com
The nuclear factor-κB (NF-κB) signaling pathway is one of the most well-studied pathways
related to inflammation, and its involvement in aging has attracted considerable attention. As …
related to inflammation, and its involvement in aging has attracted considerable attention. As …
Modelling the molecular mechanisms of aging
MT Mc Auley, AM Guimera, D Hodgson… - Bioscience …, 2017 - portlandpress.com
The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …
accumulates with age. Although cells possess mechanisms to repair or remove damage …
Mechanisms of protein quality control in the endoplasmic reticulum by a coordinated Hsp40-Hsp70-Hsp90 system
JLM Kotler, TO Street - Annual review of biophysics, 2023 - annualreviews.org
The Hsp40, Hsp70, and Hsp90 chaperone families are ancient, highly conserved, and
critical to cellular protein homeostasis. Hsp40 chaperones can transfer their protein clients to …
critical to cellular protein homeostasis. Hsp40 chaperones can transfer their protein clients to …
Systems biology for smart crops and agricultural innovation: filling the gaps between genotype and phenotype for complex traits linked with robust agricultural …
In recent years, rapid developments in several omics platforms and next generation
sequencing technology have generated a huge amount of biological data about plants …
sequencing technology have generated a huge amount of biological data about plants …
Harmonizing semantic annotations for computational models in biology
Life science researchers use computational models to articulate and test hypotheses about
the behavior of biological systems. Semantic annotation is a critical component for …
the behavior of biological systems. Semantic annotation is a critical component for …