Cytokines function as communication tools of the immune system, serving critical functions
in many biological responses and shaping the immune response. When cytokine production …

Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can
induce progressive disability if not properly treated early. Over the last 20 years, the …

Objectives To estimate the association of Janus kinase inhibitors (JAKi) with the incidence of
malignancy, compared with placebo, tumour necrosis factor (TNF)-α inhibitors (TNFi) and …

Janus kinase inhibitors (JAKi) have enormous appeal as immune-modulating therapies
across many chronic inflammatory diseases, but recently this promise has been …

Introduction This article aims to describe malignancies in patients with rheumatoid arthritis
(RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), or non-radiographic axial …

Patients with Immune-Mediated Inflammatory Diseases (IMIDs) are known to have an
elevated risk of developing cancer, but the exact causative factors remain subject to ongoing …

Rheumatoid arthritis (RA) remains a challenging autoimmune disease due to its complex
and heterogeneous pathophysiology, which complicates therapeutic and diagnostic efforts …

Background: Janus kinase (JAK) inhibitors are promising for inflammatory bowel diseases
(IBDs), but their long-term safety, including risks of nonmelanoma skin cancer (NMSC), is …

Importance The Oral Rheumatoid Arthritis Trial Surveillance demonstrated an increased
cancer risk among patients with rheumatoid arthritis (RA) taking tofacitinib compared with …

Background Evolving evidence suggests that patients undergoing treatment with Janus
kinase inhibitors (JAKi) may face an increased risk of cardiovascular events, malignancies …