Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Since its discovery in 1988 as an endothelial cell-derived peptide that exerts the most potent
vasoconstriction of any known endogenous compound, endothelin (ET) has emerged as an …

Based on the reports reviewed in here, targeting of the renal endothelin system is a possible
therapeutic approach against the development of glomerular injury. More animal and clinical …

NaCl absorption along the nephron is regulated not just by humoral factors but also by
factors that do not circulate or act on the cells where they are produced. Generally, nitric …

Background Premenopausal women are less likely to develop hypertension and salt‐related
complications than are men, yet the impact of sex on mechanisms regulating Na+ …

The renal medullary microcirculation is a distinctive arrangement of blood vessels that serve
multiple functions in the renal medulla. This article begins with a description of the unique …

Highlights•The endothelin system is a critical renal regulator of salt and water
homeostasis.•Renal ET B receptor function is impaired in hypertensive males.•Endothelin …

Autocrine and paracrine signaling in the kidney adds an extra level of diversity and
complexity to renal physiology. The extensive scientific production on the topic precludes …

Aldosterone and endothelin-1 (ET-1) act on collecting duct cells of the kidney and are
important regulators of renal sodium transport and cardiovascular physiology. We recently …

The renal tubular epithelial cells produce more endothelin-1 (ET-1) than any other cell type
in the body. Moving down the nephron, the amount of ET-1 produced appears fairly …