Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …

Host innate immune sensors are vital for the initial detection of pathogen infection. Such
sensors thus need to constantly adapt in escalating evolutionary arms races with pathogens …

African swine fever (ASF) is a viral hemorrhagic disease that affects domestic pigs and wild
boar and is caused by the African swine fever virus (ASFV). The ASFV virion contains a long …

Coronaviruses (CoVs) are a family of RNA viruses that typically cause respiratory, enteric,
and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus …

The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …

Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …

For over 15 years the lytic cell death termed pyroptosis was defined by its dependency on
the inflammatory caspase, caspase-1, which, upon pathogen sensing, is activated by innate …

The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread despite the global
efforts taken to control it. The 3C-like protease (3CLpro), the major protease of SARS-CoV-2 …

It is well-known that viruses activate various inflammasomes, which can initiate the
programmed cell death pathway known as pyroptosis, subsequently leading to cell lysis and …

Gasdermins (GSDM) are a family of six homologous proteins (GSDMA to E and Pejvakin) in
humans. GSDMA-E are pore-forming proteins targeting the plasma membrane to trigger a …