Transporters in the mammary gland—contribution to presence of nutrients and drugs into milk

AM García-Lino, I Álvarez-Fernández… - Nutrients, 2019 - mdpi.com
A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …

Increased MDR1 transporter expression in human brain endothelial cells through enhanced histone acetylation and activation of aryl hydrocarbon receptor signaling

D You, X Wen, L Gorczyca, A Morris… - Molecular …, 2019 - Springer
Abstract Multidrug resistance protein 1 (MDR1, ABCB1, P-glycoprotein) is a critical efflux
transporter that extrudes chemicals from the blood–brain barrier (BBB) and limits neuronal …

Histone deacetylase inhibitors regulate vitamin C transporter functional expression in intestinal epithelial cells

VS Subramanian, T Teafatiller, H Moradi… - The Journal of …, 2021 - Elsevier
Intestinal absorption of vitamin C in humans is mediated via the sodium-dependent vitamin
C transporters (hSVCT1 and hSVCT2). hSVCT1 and hSVCT2 are localized at the apical and …

[HTML][HTML] HDACIs and TKIs combinations and their liposomal delivery for cancer treatment

C Schelker, P Nowak-Sliwinska, G Borchard - Journal of Controlled …, 2023 - Elsevier
Fixed-drug combinations have been used for the treatment of cancer. Current anticancer
therapies, however, tend to induce resistance and provoke important toxicity. Therefore …

Epigenetic regulation of ferroportin in primary cultures of the rat blood-brain barrier

SS Helgudottir, LJ Routhe, A Burkhart, K Jønsson… - Molecular …, 2020 - Springer
Ferroportin plays an essential role for iron transport through the blood-brain barrier (BBB),
which is formed by brain capillary endothelial cells (BCECs). To maintain the integrity of the …

Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells

T Teafatiller, S Subramanian, FE Marquez, M Kitazawa… - Life Sciences, 2022 - Elsevier
Neuronal uptake of ascorbic acid (AA) in humans occurs via the human sodium-dependent
vitamin C transporter-2 (hSVCT2). Recent studies show that a significantly lower level of …

[引用][C] Epigenetic regulation of multidrug resistance protein 1 and breast cancer resistance protein transporters by histone deacetylase inhibition

D You, JR Richardson, LM Aleksunes - Drug Metabolism and Disposition, 2020 - ASPET

Targeting ACSS2 activity suspends the formation of chemoresistance through suppressed histone H3 acetylation in human breast cancer

X Shui, L Tian, Y Zhou, B Zhao - 2024 - researchsquare.com
Histone hyperacetylation is a prevalent occurrence in neoplastic cells within tumors, arising
from the coordinated interplay of various biological processes. This phenomenon relies on …

[引用][C] Murine central nervous system and bone marrow distribution of the aurora a kinase inhibitor alisertib: Pharmacokinetics and exposure at the sites of efficacy and …

JH Oh, EA Power, W Zhang, DJ Daniels… - Journal of Pharmacology …, 2022 - ASPET

[图书][B] Zyklische Hybride-Rigide Modellstrukturen für neue Theranostika

C Herlan - 2021 - books.google.com
Die hoch variable Strukturklasse der Peptide zeichnet sich durch Vertreter mit großem
Potenzial in biochemischen und medizinischen Forschungsbereichen aus. Das …