Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Machine learning applications for mass spectrometry-based metabolomics

UW Liebal, ANT Phan, M Sudhakar, K Raman… - Metabolites, 2020 - mdpi.com
The metabolome of an organism depends on environmental factors and intracellular
regulation and provides information about the physiological conditions. Metabolomics helps …

Biologically informed deep learning to query gene programs in single-cell atlases

M Lotfollahi, S Rybakov, K Hrovatin… - Nature Cell …, 2023 - nature.com
The increasing availability of large-scale single-cell atlases has enabled the detailed
description of cell states. In parallel, advances in deep learning allow rapid analysis of newly …

Dealing with dimensionality: the application of machine learning to multi-omics data

D Feldner-Busztin, P Firbas Nisantzis… - …, 2023 - academic.oup.com
Motivation Machine learning (ML) methods are motivated by the need to automate
information extraction from large datasets in order to support human users in data-driven …

Democratizing knowledge representation with BioCypher

S Lobentanzer, P Aloy, J Baumbach, B Bohar… - Nature …, 2023 - nature.com
Biomedical data are amassed at an ever-increasing rate, and machine learning tools that
use prior knowledge in combination with biomedical big data are gaining much traction 1, 2 …

Integrating knowledge and omics to decipher mechanisms via large‐scale models of signaling networks

M Garrido‐Rodriguez, K Zirngibl, O Ivanova… - Molecular systems …, 2022 - embopress.org
Signal transduction governs cellular behavior, and its dysregulation often leads to human
disease. To understand this process, we can use network models based on prior …

Machine learning approaches to predict drug efficacy and toxicity in oncology

BA Badwan, G Liaropoulos, E Kyrodimos, D Skaltsas… - Cell reports …, 2023 - cell.com
In recent years, there has been a surge of interest in using machine learning algorithms
(MLAs) in oncology, particularly for biomedical applications such as drug discovery, drug …

Automated assembly of molecular mechanisms at scale from text mining and curated databases

JA Bachman, BM Gyori, PK Sorger - Molecular Systems Biology, 2023 - embopress.org
The analysis of omic data depends on machine‐readable information about protein
interactions, modifications, and activities as found in protein interaction networks, databases …

Rapid multi-omics sample preparation for mass spectrometry

LK Muehlbauer, A Jen, Y Zhu, Y He… - Analytical …, 2023 - ACS Publications
Multi-omics analysis is a powerful and increasingly utilized approach to gain insight into
complex biological systems. One major hindrance with multi-omics, however, is the lengthy …

The need for an integrated multi‐OMICs approach in microbiome science in the food system

I Ferrocino, K Rantsiou, R McClure… - … Reviews in Food …, 2023 - Wiley Online Library
Microbiome science as an interdisciplinary research field has evolved rapidly over the past
two decades, becoming a popular topic not only in the scientific community and among the …