[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

R Suzuki, D Yamasoba, I Kimura, L Wang, M Kishimoto… - Nature, 2022 - nature.com
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern. In
this study, our statistical modelling suggests that Omicron has spread more rapidly than the …

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA. 2

R Uraki, M Kiso, S Iida, M Imai, E Takashita, M Kuroda… - Nature, 2022 - nature.com
The recent emergence of SARS-CoV-2 Omicron (B. 1.1. 529 lineage) variants possessing
numerous mutations has raised concerns of decreased effectiveness of current vaccines …

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

J Ou, W Lan, X Wu, T Zhao, B Duan, P Yang… - … and Targeted Therapy, 2022 - nature.com
The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.
Ongoing concerns of emergent variants include possible recombinants, as genome …

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …

Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution

W Ma, H Fu, F Jian, Y Cao, M Li - Nature Ecology & Evolution, 2023 - nature.com
Mutations in the SARS-CoV-2 genome could confer resistance to pre-existing antibodies
and/or increased transmissibility. The recently emerged Omicron subvariants exhibit a …

Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

A Feng, S Bevins, J Chandler, TJ DeLiberto… - Nature …, 2023 - nature.com
SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between
people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed …

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

TN Starr, AJ Greaney, WW Hannon, AN Loes, K Hauser… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin …

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

Y Liu, J Liu, BA Johnson, H Xia, Z Ku, C Schindewolf… - Cell reports, 2022 - cell.com
We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike
mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the …