Rapid development of an efficacious vaccine against the viral pathogen severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of the coronavirus disease …

Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …

Despite being recognized as one of the most successful public health measures, vaccination
is perceived as unsafe and unnecessary by a growing number of parents. Anti-vaccination …

Background Assessing the mortality impact of the 2009 influenza A H1N1 virus
(H1N1pdm09) is essential for optimizing public health responses to future pandemics. The …

Background Influenza vaccine effectiveness (VE) is generally interpreted in the context of
vaccine match/mismatch to circulating strains with evolutionary drift in the latter invoked to …

Sensitization of the humoral immune response to invading viruses and production of
antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of …

The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic
mismatch, but even when the match appears good, effectiveness can be surprisingly low …

Highlights•Early viral infections shape B cell response recalled against future viral
strains.•Competition between memory and naïve B cells occurs in secondary viral …

Background: The test-negative design is an increasingly popular approach for estimating
vaccine effectiveness (VE) due to its efficiency. This review aims to examine published test …