Virus glycosylation: role in virulence and immune interactions

DJ Vigerust, VL Shepherd - Trends in microbiology, 2007 - cell.com
The study of N-linked glycosylation as it relates to virus biology has become an area of
intense interest in recent years due to its ability to impart various advantages to virus survival …

Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy

S Rojekar, AD Gholap, N Togre, P Bhoj… - Journal of Controlled …, 2024 - Elsevier
In the pursuit of achieving better therapeutic outcomes in the treatment of HIV, innovative
drug delivery strategies have been extensively explored. Mannose receptors, which are …

Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways

JF Roeth, KL Collins - Microbiology and molecular biology reviews, 2006 - Am Soc Microbiol
The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …

N-linked glycosylation attenuates H3N2 influenza viruses

DJ Vigerust, KB Ulett, KL Boyd, J Madsen… - Journal of …, 2007 - Am Soc Microbiol
Over the last four decades, H3N2 subtype influenza A viruses have gradually acquired
additional potential sites for glycosylation within the globular head of the hemagglutinin (HA) …

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

L Zhao, S Wang, M Xu, Y He, X Zhang, Y Xiong… - Nature …, 2021 - nature.com
The HIV-1 accessory proteins Vif, Vpu, and Nef can promote infection by overcoming the
inhibitory effects of the host cell restriction factors APOBEC3G, Tetherin, and SERINC5 …

Vpr and its cellular interaction partners: R we there yet?

H Fabryova, K Strebel - Cells, 2019 - mdpi.com
Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is
packaged in significant quantities into virus particles through a specific interaction with the …

Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection

GE Holder, CM McGary, EM Johnson, R Zheng… - Journal of Neuroimmune …, 2014 - Springer
We examined the expression of the mannose receptor CD206 by perivascular macrophages
(PVM) in normal human and monkey brains and in brains of HIV-infected humans and of …

Host restriction factors modulating HIV latency and replication in macrophages

I Pagani, P Demela, S Ghezzi, E Vicenzi… - International Journal of …, 2022 - mdpi.com
In addition to CD4+ T lymphocytes, myeloid cells and, particularly, differentiated
macrophages are targets of human immunodeficiency virus type-1 (HIV-1) infection via the …

Vpr is a VIP: HIV vpr and infected macrophages promote viral pathogenesis

J Lubow, KL Collins - Viruses, 2020 - mdpi.com
HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here
we review the role of macrophages in HIV infection and describe complex interactions …

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

J Lubow, MC Virgilio, M Merlino, DR Collins… - Elife, 2020 - elifesciences.org
HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary
conservation of Vpr suggests an important yet poorly understood role for macrophages in …