Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered
fundamental regulators of tumorigenesis. However, the specific separation of functions that …

The decline in hematopoietic function seen during aging involves a progressive reduction in
the immune response and an increased incidence of myeloid malignancy, and has been …

Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older
patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic …

Metazoan sibling cells often diverge in activity and identity, suggesting links between growth
signals and cell fate. We show that unequal transduction of nutrient-sensitive …

Lipids are often considered membrane components whose function is to embed proteins
into cell membranes. In the last two decades, studies on brain lipids have unequivocally …

The stem cell–intrinsic model of self-renewal via asymmetric cell division (ACD) posits that
fate determinants be partitioned unequally between daughter cells to either activate or …

The Rho family of guanosine triphosphatases (GTP ases) is composed of members of the
Ras superfamily of proteins. They are GTP‐bound molecules with a modest intrinsic GTP …

Immunological protection against microbial pathogens is dependent on robust generation of
functionally diverse T lymphocyte subsets. Upon microbial infection, naïve CD4+ or CD8+ T …

Connexin-43 (Cx43), a gap junction protein involved in control of cell proliferation,
differentiation and migration, has been suggested to have a role in hematopoiesis. Cx43 is …