Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …

Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a
centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Death of hepatocytes and other hepatic cell types is a characteristic feature of liver diseases
as diverse as cholestasis, viral hepatitis, ischemia/reperfusion, liver preservation for …

Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced
liver injury (Gunawan, BK, Liu, ZX, Han, D., Hanawa, N., Gaarde, WA, and Kaplowitz …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …