Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Beautiful images of animal cells cultured on surfaces are ubiquitous in biological research,
but these shapes also carry valuable information about the cells and the organism that they …

The cell nucleus is constantly subjected to externally applied forces. During metazoan
evolution, the nucleus has been optimized to allow physical deformability while protecting …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Highlights•Both A-type and B-type lamins assembled into filaments with similar dimensions.•
Visualizing lamin filaments by cryo-ET, using variety of sample preparation approaches.•The …

Lamin A, a main constituent of the nuclear lamina, is the major splicing product of the LMNA
gene, which also encodes lamin C, lamin A delta 10 and lamin C2. Involvement of lamin A in …

Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear
processes. In mammals, A‐and B‐type lamins assemble into separate physical meshwork …

Geometrical cues provided by the intrinsic architecture of tissues and implanted biomaterials
have a high relevance in controlling cellular behavior. Knowledge of how cells sense and …