The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors
H Hou, D Sun, X Zhang - Cancer cell international, 2019 - Springer
The MDM2 protein encoded by the mouse double minute 2 (MDM2) gene is the primary
negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 …
negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 …
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
V Tisato, R Voltan, A Gonelli, P Secchiero… - Journal of hematology & …, 2017 - Springer
The two murine double minute (MDM) family members MDM2 and MDMX are at the center
of an intense clinical assessment as molecular target for the management of cancer. Indeed …
of an intense clinical assessment as molecular target for the management of cancer. Indeed …
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy
S Shangary, S Wang - Annual review of pharmacology and …, 2009 - annualreviews.org
Tumor suppressor p53 is an attractive cancer therapeutic target because it can be
functionally activated to eradicate tumors. Direct gene alterations in p53 or interaction …
functionally activated to eradicate tumors. Direct gene alterations in p53 or interaction …
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
S Shangary, D Qin, D McEachern… - Proceedings of the …, 2008 - National Acad Sciences
We have designed MI-219 as a potent, highly selective and orally active small-molecule
inhibitor of the MDM2–p53 interaction. MI-219 binds to human MDM2 with a K i value of 5 …
inhibitor of the MDM2–p53 interaction. MI-219 binds to human MDM2 with a K i value of 5 …
MDM2 inhibitors for cancer therapy
LT Vassilev - Trends in molecular medicine, 2007 - cell.com
The tumor suppressor p53 is a powerful antitumoral molecule frequently inactivated by
mutations or deletions in cancer. However, half of all human tumors express wild-type p53 …
mutations or deletions in cancer. However, half of all human tumors express wild-type p53 …
Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas
N Vogt, SH Lefèvre, F Apiou… - Proceedings of the …, 2004 - National Acad Sciences
Amplification of the epidermal growth factor receptor gene on double minutes is recurrently
observed in cells of advanced gliomas, but the structure of these extrachromosomal circular …
observed in cells of advanced gliomas, but the structure of these extrachromosomal circular …
[HTML][HTML] A unifying model for extrachromosomal circular DNA load in eukaryotic cells
Extrachromosomal circular DNA (eccDNA) with exons and whole genes are common
features of eukaryotic cells. Work from especially tumours and the yeast Saccharomyces …
features of eukaryotic cells. Work from especially tumours and the yeast Saccharomyces …
[PDF][PDF] Small molecule inhibitors of MDM2-p53 and MDMX-p53 interactions as new cancer therapeutics
Y Zhao, D Bernard, S Wang - BioDiscovery, 2013 - biodiscovery.pensoft.net
Inactivation of the function of tumor suppressor p53 is common in human cancers. In
approximately half of human cancers, the tumor suppressor function of p53 is inactivated by …
approximately half of human cancers, the tumor suppressor function of p53 is inactivated by …
14‐3‐3γ binds to MDMX that is phosphorylated by UV‐activated Chk1, resulting in p53 activation
It has been shown that MDMX inhibits the activity of the tumor suppressor p53 by primarily
cooperating with the p53 feedback regulator MDM2. Here, our study shows that this …
cooperating with the p53 feedback regulator MDM2. Here, our study shows that this …