An increasing number of studies have reported that bacterial DNA methylation has important
functions beyond the roles in restriction-modification systems, including the ability of …

Mathematical biology and pharmacology models have a long and rich history in the fields of
medicine and physiology, impacting our understanding of disease mechanisms and the …

For decades, identifying the regions of a bacterial chromosome that are necessary for
viability has relied on mapping integration sites in libraries of random transposon mutants to …

Tuberculosis (TB) kills more individuals in the world than any other disease, and a threat
made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb) …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

The ability of Staphylococcus aureus to infect many different tissue sites is enabled, in part,
by its transcriptional regulatory network (TRN) that coordinates its gene expression to …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Transcriptional regulatory networks (TRNs) have been studied intensely for> 25 y. Yet, even
for the Escherichia coli TRN—probably the best characterized TRN—several questions …

Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to
changing environments, yet the concept of transcriptional plasticity (TP)–the variability of …

The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the
underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the single leading cause of …