The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Cells migrate in multiple different ways depending on their environment, which includes the
extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …

RAC1 is a widely studied Rho GTPase, a class of molecules that modulate numerous
cellular functions essential for normal development. RAC1 is highly conserved across …

MicroRNAs are small non-coding RNAs that participate in different biological processes,
providing subtle combinational regulation of cellular pathways, often by regulating …

Cell adhesion to the extracellular matrix is essential for cellular processes, such as migration
and invasion. In response to cues from the microenvironment, integrin-mediated adhesions …

Lung cancer is a kind of malignant tumor with rapid progression and poor prognosis. Distant
metastasis has been the main cause of mortality among lung cancer patients. Bone is one of …

Human papillomaviruses (HPVs) are small double‐stranded circular DNA viruses with 8 kb
genomes. So far, more than 150 HPVs have been identified, and 12 types of HPVs have …

Integrins engage components of the extracellular matrix, and in collaboration with other
receptors, regulate signaling cascades that impact cell behavior in part by modulating the …

To initiate directed movement, cells must become polarized, establishing a protrusive
leading edge and a contractile trailing edge. This symmetry-breaking process involves …

The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It
also regulates G2/M progression and cytokinesis completion, via CDK-dependent or …