Pepsin is a protease used in many different applications, and in many instances, it is utilized
in an immobilized form to prevent contamination of the reaction product. This enzyme has …

Immobilized-enzyme reactors (IMERs) are flow-through devices containing enzymes that are
physically confined or localized with retention of their catalytic activities. IMERs can be used …

Butyrylcholinesterase (BChE), a member of the human serine hydrolase family, is an
essential enzyme for cholinergic neurotransmission as it catalyzes the hydrolysis of …

Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is
characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by …

The objective of this study is to present and critically analyze the current state of knowledge
on the chromatographic analysis of chemical warfare agents (CWAs) and their metabolites …

Nano liquid chromatography-mass spectrometry (nLC-MS), is often a tool of choice for the
analysis of very limited samples, especially in proteomics. Although highly powerful in itself …

An online microfluidics-mass spectrometry platform was developed for determining
proteotypic peptides from in-solution digested samples. Accelerated and selective sample …

In the present work, a pair of molecularly imprinted polymers (MIPs) targeting distinct peptide
targets were packed into trap columns and combined for automated duplex analysis of two …

Upon entering the body, nerve agents can bind active amino acid residues to form
phosphonylated adducts. Tabun derivatives (O-alkyl-N, N-dialkyl …

Human butyrylcholinesterase (HuBChE) is being developed as a therapeutic for protection
from the toxicity of nerve agents. An enriched source of HuBChE is Cohn fraction IV-4 from …