Exercise mimetics: harnessing the therapeutic effects of physical activity

C Gubert, AJ Hannan - Nature Reviews Drug Discovery, 2021 - nature.com
Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

Has-miR-129-5p's involvement in different disorders, from digestive cancer to neurodegenerative diseases

A Boicean, S Birsan, C Ichim, I Boeras, I Roman-Filip… - Biomedicines, 2023 - mdpi.com
At present, it is necessary to identify specific biochemical, molecular, and genetic markers
that can reliably aid in screening digestive cancer and correlate with the degree of disease …

Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men

NS de Lima, RAL De Sousa, FT Amorim, F Gripp… - Metabolic brain …, 2022 - Springer
The prevalence of overweight and obesity is increasing worldwide, which has been
associated with poor cognitive outcomes. Participating in regular physical exercise may also …

Discerning the prospects of miRNAs as a multi-target therapeutic and diagnostic for alzheimer's disease

D Bhatnagar, S Ladhe, D Kumar - Molecular Neurobiology, 2023 - Springer
Although over the last few decades, numerous attempts have been made to halt Alzheimer's
disease (AD) progression and mitigate its symptoms, only a few have been proven …

[HTML][HTML] Exercise-linked consequences on epilepsy

BRR Cavalcante, AC Improta-Caria, VH de Melo… - Epilepsy & Behavior, 2021 - Elsevier
Objective Epilepsy is a brain disorder that leads to seizures and neurobiological, cognitive,
psychological, and social consequences. Physical inactivity can contribute to worse epilepsy …

All roads lead to Rome—a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease

YY Liang, LD Zhang, X Luo, LL Wu… - Neural regeneration …, 2022 - journals.lww.com
Age-related neurodegenerative disorders such as Alzheimer's disease (AD) have become a
critical public health issue due to the significantly extended human lifespan, leading to …

MicroRNAs regulating renin–angiotensin–aldosterone system, sympathetic nervous system and left ventricular hypertrophy in systemic arterial hypertension

AC Improta-Caria, MG Aras, L Nascimento… - biomolecules, 2021 - mdpi.com
MicroRNAs are small non-coding RNAs that regulate gene and protein expression.
MicroRNAs also regulate several cellular processes such as proliferation, differentiation, cell …

Physical exercise and immune system: perspectives on the COVID-19 pandemic

AC Improta-Caria, ÚPR Soci, CS Pinho… - Revista da Associação …, 2021 - SciELO Brasil
Physical exercise training (PET) has been considered an excellent non-pharmacological
strategy to prevent and treat several diseases. There are various benefits offered by PET …

Mini review: The relationship between energy status and adult hippocampal neurogenesis

T Landry, H Huang - Neuroscience letters, 2021 - Elsevier
The ability to generate new hippocampal neurons throughout adulthood and successfully
integrate them into existing neural networks is critical to cognitive function, while disordered …

Can exercise benefits be harnessed with drugs? A new way to combat neurodegenerative diseases by boosting neurogenesis

R Zhao - Translational Neurodegeneration, 2024 - Springer
Adult hippocampal neurogenesis (AHN) is affected by multiple factors, such as enriched
environment, exercise, ageing, and neurodegenerative disorders. Neurodegenerative …