Low back pain and osteoarthritis pain: a perspective of estrogen

H Pang, S Chen, DM Klyne, D Harrich, W Ding… - Bone Research, 2023 - nature.com
Low back pain (LBP) is the world's leading cause of disability and is increasing in
prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) …

Female aging: when translational models don't translate

G Gilmer, ZR Hettinger, Y Tuakli-Wosornu, E Skidmore… - Nature aging, 2023 - nature.com
For many pathologies associated with aging, female patients present with higher morbidity
and more frequent adverse events from treatments compared to male patients. While …

Epigenetic modification and exosome effects on autophagy in osteoarthritis

C Cheng, Y Wu, Y Huang, Q Xue, Y Wang… - Biochemical …, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative disease that leads to joint pain and stiffness and is one
of the leading causes of disability and pain worldwide. Autophagy is a highly conserved self …

[HTML][HTML] S-Equol ameliorates menopausal osteoarthritis in rats through reducing oxidative stress and cartilage degradation

YC Hu, TC Huang, LW Huang, HL Cheng, BS Hsieh… - Nutrients, 2024 - mdpi.com
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage
destruction. Menopausal and postmenopausal women are susceptible to both OA and …

Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage

G Gilmer, H Iijima, ZR Hettinger, N Jackson… - Nature Aging, 2025 - nature.com
Female individuals who are post-menopausal present with higher incidence of knee
osteoarthritis (KOA) than male counterparts; however, the mechanisms underlying this …

A network medicine approach to elucidate mechanisms underlying menopause-induced knee osteoarthritis

G Gilmer, H Iijima, N Jackson, Z Hettinger, AC Bean… - bioRxiv, 2023 - biorxiv.org
Post-menopausal women present with the highest incidence and morbidity of knee
osteoarthritis (KOA), but no disease-modifying therapies are available. This treatment gap …

Sex considerations in Regenerative Rehabilitation strategies for the treatment of knee osteoarthritis

H Iijima, R Nakahara, A Ito - Current Opinion in Biomedical Engineering, 2024 - Elsevier
Regenerative rehabilitation is a promising field aimed at harnessing the regenerative
potential of stem cell therapeutics to maximize functional recovery. Here, we outline recent …

[HTML][HTML] The association between sex hormones and prevalence of OA in US adults

X Tian, B Zhang - Frontiers in Medicine, 2024 - pmc.ncbi.nlm.nih.gov
Background Age and gender are commonly recognized as risk factors for osteoarthritis (OA),
implying a potential association between sex hormones and OA pathogenesis. However, the …

Sex specific knee joint soft tissue mineralization with Fibrillin-1 mutation in male Tight Skin mice.

C Keenan, X Wang, T Dikmen, Y Wen, L Ramos-Mucci… - bioRxiv, 2024 - biorxiv.org
Articular soft tissue mineralization and ossification are clear pathological signs of
osteoarthritis joints. However their molecular and cellular aetiologies remain largely …

Osteoarthritis, social role participation, and satisfaction with life: A quantitative study informed by the Social Identity Model of Identity Change (SIMIC)

SE Rosado - 2024 - digitalcommons.usf.edu
This cross-sectional survey study utilized an adapted version of the Social Identity Model of
Identity Change (SIMIC) to investigate associations between post-diagnostic factors, role …