ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for …

The E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …

Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …

Apolipoprotein E (APOE) is a multifunctional protein synthesized and secreted by multiple
mammalian tissues. Although hepatocytes contribute about 75% of the peripheral pool …

Apolipoprotein E (APOE) is a member of the vertebrate protein family of exchangeable
apolipoproteins that is characterized by amphipathic α-helices encoded by multiple …

In addition to the appearance of senile plaques and neurofibrillary tangles, Alzheimer's
disease (AD) is characterized by aberrant lipid metabolism and early mitochondrial …