Mitochondria are cellular factories for energy production, calcium homeostasis and iron
metabolism, but they also have an unequivocal and central role in intrinsic apoptosis …

Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack of
effective treatments. Interactions between cardiomyocytes and the MI microenvironment …

Mitochondrial dysfunction can elicit multiple inflammatory pathways, especially when
apoptotic caspases are inhibited. Such an inflammatory program is negatively regulated by …

Loss of proteostasis is well documented during physiological aging and depends on the
progressive decline in the activity of two major degradative mechanisms: the ubiquitin …

Spinal cord injury is a serious traumatic nervous system disorder characterized by extensive
neuronal apoptosis. Oxidative stress, a key factor in neuronal apoptosis, leads to the …

Accumulation in the brain of amyloid-β (Aβ), derived from cleavage of Aβ precursor protein
(APP), is a hallmark of Alzheimer's disease (AD). Oleanonic acid (OA), a phytochemical from …

Intensification of poultry industry has led to a surge in animal product output, but this has
also revealed issues with environmental management in poultry houses, particularly the …

Cochlear outer hair cells (OHCs) play a fundamental role in the hearing sensitivity and
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …

Selenoprotein M (SELENOM) has emerged as a crucial factor in maintaining cellular redox
homeostasis and mitigating oxidative damage. This study aims to investigate its protective …

Mitochondrial dynamics and mtDNA homeostasis are critical in various biological processes,
including cell fate determination, metabolism, and aging. Although specialized mitochondrial …