Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Advanced techniques for detecting protein misfolding and aggregation in cellular environments
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
Aggfluor: fluorogenic toolbox enables direct visualization of the multi-step protein aggregation process in live cells
Aberrantly processed or mutant proteins misfold and assemble into a variety of soluble
oligomers and insoluble aggregates, a process that is associated with an increasing number …
oligomers and insoluble aggregates, a process that is associated with an increasing number …
Miniaturized chemical tags for optical imaging
Recent advances in optical bioimaging have prompted the need for minimal chemical
reporters that can retain the molecular recognition properties and activity profiles of …
reporters that can retain the molecular recognition properties and activity profiles of …
Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates
Proper three-dimensional structures are essential for maintaining the functionality of proteins
and for avoiding pathological consequences of improper folding. Misfolding and …
and for avoiding pathological consequences of improper folding. Misfolding and …
Bringing vibrational imaging to chemical biology with molecular probes
As an emerging optical imaging modality, stimulated Raman scattering (SRS) microscopy
provides invaluable opportunities for chemical biology studies using its rich chemical …
provides invaluable opportunities for chemical biology studies using its rich chemical …
Quantitative stimulated Raman scattering microscopy: promises and pitfalls
B Manifold, D Fu - Annual Review of Analytical Chemistry, 2022 - annualreviews.org
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a
powerful chemical imaging tool that shows promise in numerous biological and biomedical …
powerful chemical imaging tool that shows promise in numerous biological and biomedical …
Raman spectroscopy on brain disorders: transition from fundamental research to clinical applications
Brain disorders such as brain tumors and neurodegenerative diseases (NDs) are
accompanied by chemical alterations in the tissues. Early diagnosis of these diseases will …
accompanied by chemical alterations in the tissues. Early diagnosis of these diseases will …
Observation of liquid–liquid phase separation of ataxin-3 and quantitative evaluation of its concentration in a single droplet using Raman microscopy
K Murakami, S Kajimoto, D Shibata, K Kuroi, F Fujii… - Chemical …, 2021 - pubs.rsc.org
Liquid–liquid phase separation (LLPS) plays an important role in a variety of biological
processes and is also associated with protein aggregation in neurodegenerative diseases …
processes and is also associated with protein aggregation in neurodegenerative diseases …
Unveiling cancer metabolism through spontaneous and coherent Raman spectroscopy and stable isotope probing
Simple Summary Raman spectroscopy and imaging are label-free, non-destructive
techniques to study cellular metabolism with subcellular spatial resolution. This review …
techniques to study cellular metabolism with subcellular spatial resolution. This review …