Locomotion is a universal motor behavior that is expressed as the output of many integrated
brain functions. Locomotion is organized at several levels of the nervous system, with …

The pontomedullary reticular formation (RF) is a key site responsible for integrating
descending instructions to execute particular movements. The indiscrete nature of this …

The brainstem is a key centre in the control of body movements. Although the precise nature
of brainstem cell types and circuits that are central to full-body locomotion are becoming …

Locomotion empowers animals to move. Locomotor-initiating signals from the brain are
funneled through descending neurons in the brainstem that act directly on spinal locomotor …

Spatial orientation requires the execution of lateralized movements and a change in the
animal's heading in response to multiple sensory modalities. While much research has …

An approaching predator and self-motion toward an object can generate similar looming
patterns on the retina, but these situations demand different rapid responses. How central …

The mesencephalic locomotor region (MLR) serves as an interface between higher-order
motor systems and lower motor neurons. The excitatory module of the MLR is composed of …

The representation of contextual information peripheral to a salient stimulus is central to an
animal's ability to correctly interpret and flexibly respond to that stimulus. While the …

Spinal cord injury (SCI) often results in life-long sensorimotor impairment. Spontaneous
recovery from SCI is limited, as supraspinal fibers cannot spontaneously regenerate to form …

A series of recent studies identified key structures in the mesencephalic locomotor region
and the caudal brainstem of mice involved in the initiation and control of slow (exploratory) …