Hippocampus is the significant component of the limbic lobe, which is further subdivided into
the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for learning and …

Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity …

Human episodic memory critically depends on subregions of the medial temporal lobe,
which are part of functional brain systems such as the anterior-temporal and the posterior …

In Alzheimer's disease, post-mortem studies have shown that the first cortical site where
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …

Importance In vivo tau imaging may become a diagnostic marker for Alzheimer disease (AD)
and provides insights into the pathophysiology of AD. Objective To evaluate the usefulness …

Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of
Alzheimer's disease, progressive supranuclear palsy, Pick's disease and other sporadic …

Tauopathies are neurodegenerative disorders that affect distinct brain regions, progress at
different rates, and exhibit specific patterns of tau accumulation. The source of this diversity …

In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …