Macrophages and the recovery from acute and chronic inflammation

K Hamidzadeh, SM Christensen, E Dalby… - Annual review of …, 2017 - annualreviews.org
In recent years, researchers have devoted much attention to the diverse roles of
macrophages and their contributions to tissue development, wound healing, and …

Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota

J Li, Y Ji, N Chen, L Dai, H Deng - Cell & Bioscience, 2023 - Springer
Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main
causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative …

Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation

Y Sakamoto, K Sasaki, M Omatsu… - The Journal of …, 2023 - Wiley Online Library
Disruption of the intestinal epithelial barrier and dysregulation of macrophages are major
factors contributing to the pathogenesis of inflammatory bowel diseases (IBDs). Activation of …

Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury

Y Pan, S Cao, AS Terker, J Tang, K Sasaki, Y Wang… - Kidney international, 2022 - Elsevier
Following acute injury to the kidney, macrophages play an important role in recovery of
functional and structural integrity, but organ fibrosis and progressive functional decline occur …

EP4 receptor as a novel promising therapeutic target in colon cancer

V Karpisheh, N Joshi, AO Zekiy, B Beyzai… - … -Research and Practice, 2020 - Elsevier
The most prevalent malignancy that can occur in the gastrointestinal tract is colon cancer.
The current treatment options for colon cancer patients include chemotherapy, surgery …

mPGES-1 and ALOX5/-15 in tumor-associated macrophages

A Weigert, E Strack, RG Snodgrass, B Brüne - Cancer and Metastasis …, 2018 - Springer
The tumor immune landscape gained considerable interest based on the knowledge that
genetic aberrations in cancer cells alone are insufficient for tumor development …

[HTML][HTML] The positive effect of selective prostaglandin E2 receptor EP2 and EP4 blockade on cystogenesis in vitro is counteracted by increased kidney inflammation in …

M Lannoy, MK Valluru, L Chang, F Abdela-Ali… - Kidney International, 2020 - Elsevier
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a major cause of end-stage
kidney disease in man. The central role of cyclic adenosine monophosphate (cAMP) in …

Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP) 2/EP4-cAMP-EPAC-dependent pathway

SK Samuchiwal, B Balestrieri, H Raff… - Journal of Biological …, 2017 - ASBMB
When activated through toll-like receptors (TLRs), macrophages generate IL-33, an IL-1
family member that induces innate immune responses through ST2 signaling. LPS, a TLR4 …

Dietary Supplementation with Sea Bass (Lateolabrax maculatus) Ameliorates Ulcerative Colitis and Inflammation in Macrophages through Inhibiting Toll-Like …

J Chen, M Jayachandran, W Zhang, L Chen… - International Journal of …, 2019 - mdpi.com
Sea bass (Lateolabrax maculatus) is a kind of food material commonly consumed in daily
life. In traditional Chinese medicinal books, it has been indicated that sea bass can be …

TIMP1 Is A Potential Key Gene Associated With The Pathogenesis And Prognosis Of Ulcerative Colitis-Associated Colorectal Cancer

R Huang, K Wang, L Gao, W Gao - OncoTargets and therapy, 2019 - Taylor & Francis
Purpose Colorectal cancer (CRC) is the third most frequently diagnosed cancer worldwide.
As a high-risk factor for CRC, ulcerative colitis (UC) has been demonstrated to lead to …