Evolution of the SARS-CoV-2 Omicron spike

RJ Parsons, P Acharya - Cell reports, 2023 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern, first identified in November 2021, rapidly spread worldwide and diversified into …

Exploring multivalent carbohydrate–protein interactions by NMR

JI Quintana, U Atxabal, L Unione, A Ardá… - Chemical Society …, 2023 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features
of glycan–protein molecular recognition events. Different types of qualitative and quantitative …

Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

SJL Petitjean, W Chen, M Koehler, R Jimmidi… - Nature …, 2022 - nature.com
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent
need to better understand the molecular details of the virus binding to its host cell and to …

Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid

MA Díaz-Salinas, A Jain, ND Durham, JB Munro - Science Advances, 2024 - science.org
Conformational dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) spike glycoprotein (S) mediate exposure of the binding site for the cellular receptor …

Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19

DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …

Host membranes as drivers of virus evolution

M Matveeva, M Lefebvre, H Chahinian, N Yahi… - Viruses, 2023 - mdpi.com
The molecular mechanisms controlling the adaptation of viruses to host cells are generally
poorly documented. An essential issue to resolve is whether host membranes, and …

Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

M Monti, E Milanetti, MT Frans, M Miotto… - The Journal of …, 2024 - ACS Publications
It is not well understood why severe acute respiratory syndrome (SARS)-CoV-2 spreads
much faster than other β-coronaviruses such as SARS-CoV and Middle East respiratory …

Quantitative profiling of N-glycosylation of SARS-CoV-2 spike protein variants

Y Xie, M Butler - Glycobiology, 2023 - academic.oup.com
With the global spread of the corona virus disease-2019 pandemic, new spike variants of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continuously emerge due …

Heparan sulfate and sialic acid in viral attachment: Two sides of the same coin?

IE Ramos-Martínez, E Ramos-Martínez… - International Journal of …, 2022 - mdpi.com
Sialic acids and heparan sulfates make up the outermost part of the cell membrane and the
extracellular matrix. Both structures are characterized by being negatively charged, serving …