The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …

CD8+ T-cells are a critical component of the cellular immune response and they play an
important role in the control of viral infection. During HIV infection, CD8+ T-cells are able to …

The CTL response plays a central part in deciding the outcome of viral infections. Evidence
from host and viral genetics, gene expression microarrays and assays of T‐cell phenotype …

To facilitate viral infection and spread, HIV-1 Nef disrupts the surface expression of the viral
receptor (CD4) and molecules capable of presenting HIV antigens to the immune system …

In the current study, we evaluated whether the capacity of HIV to modulate major
histocompatibility complex (MHC) class I molecules has an impact on the ability of …

CD8+ T cells play a crucial role in the control of viral infections by direct elimination of
infected cells and secretion of a number of soluble factors. Recent data suggest that HIV-1 …

Background Development of AIDS vaccines for effective prevention of circulating HIV-1 is
required, but no trial has demonstrated definitive effects on the prevention. Several recent T …

HIV-1 Nef triggers down-regulation of cell-surface MHC-I by assembling a Src family kinase
(SFK)-ZAP-70/Syk-PI3K cascade. Here, we report that chemical disruption of the Nef-SFK …

Human immunodeficiency virus, type 1 Nef disrupts viral antigen presentation and promotes
viral immune evasion from cytotoxic T lymphocytes. There is evidence that Nef acts early in …

Cytotoxic T lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and
recognize circulating HIV-1 could be key for both HIV-1 cure and prophylaxis. We recently …