Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Biological membranes are complex and dynamic assemblies of lipids and proteins.
Poikilothermic organisms including bacteria, fungi, reptiles, and fish do not control their body …

Cell membranes contain hundreds of different proteins and lipids in an asymmetric
arrangement. Our current understanding of the detailed organization of cell membranes …

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an
important aspect of the rewired metabolism of transformed cells. However, the contribution of …

Background Extracellular vesicles (EVs) are attractive candidate drug delivery systems due
to their ability to functionally transport biological cargo to recipient cells. However, the …

Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …

Cell membranes are composed of a lipid bilayer, containing proteins that span the bilayer
and/or interact with the lipids on either side of the two leaflets. Although recent advances in …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …