[HTML][HTML] NRF2, a transcription factor for stress response and beyond
F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …
cellular defense against toxic and oxidative insults through the expression of genes involved …
[HTML][HTML] The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
Activators and inhibitors of NRF2: a review of their potential for clinical development
N Robledinos-Antón… - Oxidative medicine …, 2019 - Wiley Online Library
The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …
line of homeostatic responses against a plethora of environmental or endogenous …
Endoplasmic reticulum–associated protein degradation
L Krshnan, ML van de Weijer… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
[HTML][HTML] NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
[HTML][HTML] Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1α signaling pathways
Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
S Cadenas - Free Radical Biology and Medicine, 2018 - Elsevier
Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …
such as stroke and myocardial infarction. IR injury is mediated by several factors including …
[HTML][HTML] Nutrition strategy and life style in polycystic ovary syndrome—Narrative review
M Szczuko, J Kikut, U Szczuko, I Szydłowska… - Nutrients, 2021 - mdpi.com
Here we present an extensive narrative review of the broadly understood modifications to
the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was …
the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was …